Approvals, trial readouts and the science behind new treatments. Every ticker item and desk story tagged [MED], newest first, each with its Why it matters.
[MED] FDA approved Hibsago, the first drug of its kind for chronic hepatitis B; in trials, 19% of patients kept the virus in check 24 weeks after stopping all treatment.Why it matters
most people with hepatitis B take pills for life; this offers some a chance to stop.
[MED] FDA granted accelerated approval to the immunotherapy Jemperli for a genetic subtype of rectal cancer; 68% of patients had no visible cancer after 12 months.Why it matters
for these patients, a drug may replace surgery that can change daily life permanently.
[MED] Merck and Moderna reported that their personalized melanoma vaccine, given with immunotherapy, lowered the risk of the cancer returning, or death, by 42% in a Phase 3 trial.Why it matters
a vaccine built from a patient's own tumor is closer to becoming a standard cancer treatment.
[MED] Hepatitis B patients get a chance to stop treatment
For some patients, the daily pills could one day stop. Illustration: Singularity Nightly (AI-generated)
The FDA approved Hibsago (bepirovirsen) from GSK, the first antisense medicine for chronic hepatitis B. It works by blocking the virus's genetic instructions. In trials, 19% of patients kept the virus controlled 24 weeks after stopping all treatment.
[MED] A personalized cancer vaccine passes a major test
A vaccine made for one patient's own cancer. Illustration: Singularity Nightly (AI-generated)
Merck and Moderna reported Phase 3 results for their melanoma vaccine, which is designed from each patient's own tumor and given with the immunotherapy Keytruda. After two years, 82.2% of patients were free of recurrence versus 70.0% on Keytruda alone, per Fierce Biotech.